leaky gut – Shield Nutraceuticals

Bad Actors

by Steve in Articles, Digestion and Immunity March 21, 2023

We mention “bad actors” frequently on our website because there are so many of them in the industrialized food supply. It is our goal to raise awareness about this fact so that we might contribute to improving your health. To better understand what these bad actors are and why they are a problem, keep reading. Gluten Gluten is a blessing and a curse. It is responsible for giving bread and other baked goods their wonderfully chewy, elastic texture. However, recent evidence tells us that it is also very difficult to digest and responsible for immune activation and leaky gut in many individuals. Gluten works in bread by forming an elastic web, which traps air and carbon dioxide during baking, leading to a fluffy, squishy lattice. This makes for fantastic texture in baked goods. Just think of a fresh-baked, still steaming roll. Gluten works in your small intestine by binding to special receptors that signal a hormone to loosen the tight junctions between the cells there. This makes for less-than-fantastic opportunities for gluten and the other bad actors to trigger an immune response, causing damage to your cells. Just think of bloating, indigestion and gut pain. The long-term effects of gluten exposure are worse than indigestion and gut pain, though. Researchers have theorized that repeatedly weakening the tight junctions of your gut by exposing it to gluten almost continually could be one of the steps to autoimmune diseases. Lectins Plant lectins are a blessing for plants but a curse for all of us. Lectins are found in nearly 40% of the American food supply but wheat is the worst source. Plants evolved these lectins to work as deterrents to their predators. They are proteins that are really good at sticking to the sugars in our cells. After they are good and stuck, they can actually destroy the cells they are stuck to. Just like gluten, this creates opportunity for lectins and other bad actors to get past the wall and into the bloodstream Again, researchers fear that over time and with repeated exposure, this weakening of the integrity of the gut wall could open the door for chronic inflammatory and autoimmune diseases. We call lectins ninjas because they have been secretly assassinating cells in our gut for a long time. The science shining a light on these ninjas is called lectinology and is relatively new. Lectinology has found that we can protect ourselves from these ninjas by using decoy sugars. Bad Yeast and Bacteria Our bodies are home to billions of bacteria and yeast all of the time. Most of the time, they are helping us by digesting things that we can’t, making vitamins, and boosting our immune system. Sometimes, however, certain yeast and bacteria can get out of control and cause problems. Think of the situation like a house party. Lots of people are there and most of them are having a great time and improving the atmosphere with their jolliness and good mood. But there are always a few people at parties that just have to take it too far. They drink too much, they make too much noise, they go into parts of the house you asked them not to and sometimes they break stuff. Your gut is just like that – most of the yeast and bacteria are there having a great time and making the place better but there are a few of the party goers that will take it too far if given the chance. A way to prevent this is by taking a high quality probiotic. The term probiotic is a fancy way of saying “good bacteria.” Probiotics are like a really well thought out party invite list. You’re putting only good, well behaved bacteria into your gut so that everyone has a great time and the environment is made better. Undigested Fats, Carbohydrates, and Proteins It is a little unfair of us to call these bad actors because they are just foods that are minding their own business but accidentally find themselves where they are not wanted. The immune system is not particularly understanding about things being where they are not supposed to be in the body. Undigested foods that stumble through the holes in a leaky gut get treated just like any other invader. Fats, carbohydrates, and proteins need to be broken down into their building blocks before the body can use them. When gluten or lectins put holes in the wall, sometimes these foods slip through before they are small enough to be used and this can activate the immune system. There are two good ways to minimize the risk of this happening: heal the gut wall and provide extra enzymes to more quickly break these foods down. Enzymes are chemicals that the body uses to break foods into small enough parts for absorption. As you know, not all foods are created nutritionally equal. This applies to the digestibility of foods as well. We’ve covered how gluten and lectins are resistant to digestion but they are not the only ones: Lactose, the sugar found in dairy products, and phytate, the storage form of phosphorus in plants, can also be difficult to break down.

In-Depth Look at Dietary Bad Actors

by Steve in Articles, Bad Actors March 15, 2023

Dietary Bad Actors Dietary bad actors refer to things we eat which can cause digestive distress or illness. The things we eat were not created equal. Some are a benefit to us and others can be dangerous. There are some foods that contain what has become known as “anti-nutrients” that are always a problem and others that can become a problem in certain situations. We call these problematic foods dietary bad actors and they are the focus of our research at Shield Nutraceuticals. We developed DigestShield® to help mitigate the damage that these dietary bad actors can cause. Gluten The term gluten refers to a compound of two storage proteins found in the endosperm of wheat, barley, and rye. The proteins glutenin and gliadin are bound together with starch inside the wheat germ. These proteins provide many functional properties when used in baking and are the main source of protein in those grains. (1) Of the two proteins in gluten, glutenin is the most important for baking, having the greatest effect on elasticity and texture of the final product. (2) Gliadin is the protein fraction that causes problems during human digestion and the protein that triggers an immune response in the body after ingestion. (3) Gliadin has been shown to produce both innate and adaptive immune responses and is thought to be involved with the pathogenesis of many autoimmune diseases. Most importantly to note, it has recently been shown that gliadin can promote an immune response in individuals with or without the genetic predisposition for reaction. (4) In addition to an immune and inflammatory response, gliadin also contributes to the development of a condition known as leaky gut in which intestinal permeability is increased and molecules of inappropriate size are allowed through the intestinal wall. Immune Response It has long been understood that gliadin produced an immune response in those with celiac disease (5) but recently researchers have discovered that gliadin also produces an immune response in healthy individuals. (6) The immune response is not uniform among individuals and a differing severity of response is not well understood. Most likely, as with all immunity, it is based upon a variety of factors including genetic susceptibility, intestinal permeability, environmental factors, gut flora, and overall health. Innate Immunity Though it is still not well understood, it has been shown that gliadin can trigger a response from the innate immune system and cause intestinal and extra-intestinal symptoms in non-celiac individuals. (6-8) In individuals with celiac disease, the innate immune system trigger is a precursor to adaptive immunity involvement. A large part of gliadin’s ability to elicit a response from the innate immune system is based upon its resistance to degradation (9) by the digestive process and its ability to cross the epithelial wall relatively intact. This allows gliadin, as a macromolecule, access to areas where many innate immune cells are found and the interaction is inevitable. Once this interaction occurs, gliadin shows the ability to activate undifferentiated immune cells that then proliferate while simultaneously producing pro-inflammatory hormones. This hormone production results in several downstream inflammatory responses. (10) Adaptive Immunity Though the adaptive immune system does not appear to play a role in the deleterious effects that gluten has on healthy, non-celiac individuals, gliadin very demonstrably activates the adaptive immune response in genetically susceptible individuals. (5) The immune response triggered in celiac individuals is varied and aggressive. It includes activation of T-cells, and eventually the autoimmune targeting of tissue transglutaminase in the body’s cells. (11) Leaky Gut The potentially greater threat posed by gluten is the role that it plays in intestinal permeability. For reasons not yet understood, gliadin has the ability to bind to receptors in the intestine that signal for the release of a hormone, which promotes the tight junctions of the epithelial cells to be degraded. Once these tight junctions are opened gliadin, as well as other pathogens, can bypass the physical barrier of the gut and interact directly with immune cells. (12) Plant Lectins Lectin is a broad term for a class of proteins found in all plants and animals. We have lectins in our bodies that serve a wide variety of functions including regulation of serum protein levels, removal of glycoproteins from the circulatory system, and mediation of important immune functions. (13) However, many of the plants that are part of our food supply contain lectins with a very different and specific function: defense. Lectins are the defense mechanism against predators, including fungi, that seek to eat the plant. Lectins are designed to cause digestive distress to keep predators away. Lectins are found in the greatest concentration in grains (especially wheat), legumes such as soy, nuts, and seeds, and nightshade vegetables. It has been estimated that there are concentrated sources of lectins in 30-40 percent of the American diet (14) though that figure is more than likely higher as the survey of foods it is based on was done in 1980 and our food supply has become more filled with wheat, soy, and potato based processed foods since then. [fusion_builder_container hundred_percent=”yes” overflow=”visible”][fusion_builder_row][fusion_builder_column type=”1_1″ background_position=”left top” background_color=”” border_size=”” border_color=”” border_style=”solid” spacing=”yes” background_image=”” background_repeat=”no-repeat” padding=”” margin_top=”0px” margin_bottom=”0px” class=”” id=”” animation_type=”” animation_speed=”0.3″ animation_direction=”left” hide_on_mobile=”no” center_content=”no” min_height=”none”] Much like gluten, lectins have been shown to be resistant to cooking and the digestive process. (15) Because they are not degraded by the human digestive process, many lectins reach the gut intact where they perform their defensive attack on the epithelial cells that line the small intestine. Though lectins may play a role in the pathogenesis of many autoimmune diseases just like gluten, the likely mechanisms are different. Unlike gluten, lectins directly damage the cells that they attach to. At first, this means epithelial cells but once a leaky gut has been created and the lectins are able to enter the bloodstream, they may attach to any of the tissues in the body. (16) Leaky Gut Lectins increase intestinal permeability by directly binding to and destroying epithelial cells. (17) Once through the epithelial barrier,

Lectins: The Gluten-Lectin-Leaky Gut Connection

by Robert Prowse in Articles, Leaky Gut February 20, 2023

After reading hundreds of articles and research papers, we started to come across several papers and theories that seemed like the pieces of a puzzle whose image was hidden. After several years and much effort, the pieces finally started fitting together to reveal a compelling picture. The following is our interpretation of what may be behind the increase in autoimmune and food-related disorders: Though it is a complicated, poorly understood, and controversial condition, we believe that leaky gut syndrome is highly relevant and may play a crucial role in the development of celiac disease, Crohn’s disease, ulcerative colitis, rheumatoid arthritis, asthma, chronic fatigue syndrome, psoriasis and much more. We understand that leaky gut syndrome is a widely debated condition and that not all health professionals believe it to be related to (or a direct cause of) disease. As research progresses, many doctors, dietitians, and researchers are becoming aware of the condition and seek ways to test for and treat it. If you haven’t heard of leaky gut syndrome, please read below: Leaky gut syndrome is the easier-to-say term for increased intestinal wall permeability. It just means that gut wall is easier to cross than it should be. The gut wall begins to be more porous and develop holes. Basically, your gut is leaking things it shouldn’t into your bloodstream. Leaky gut is thought to be caused or worsened by certain components of foods (more on that later), cytotoxic drugs, NSAIDS (non-steroidal anti-inflammatory drugs), irradiation of food, antibiotics, unbalanced gut flora, excessive alcohol consumption and compromised immunity. How It Works The intestinal lining is on the front lines of our immune system. We like to think of it as castle wall – we let the drawbridge down for visitors we know (like food and resource deliveries) but we leave it up to keep out invaders. The other layers of this sophisticated defense is called the epithelium. A single layer of epithelial cells normally stay connected together by tight junctions. These tight junctions are how the passage of nutrients is regulated in the digestive tract. The epithelial cells in the gut are tipped with finger-like projections called villi. When food is digested, villi absorb the nutrients and transport them through the epithelial cell into the bloodstream. When the digestive process is functioning normally, the tight junctions stay closed and only nutrients are allowed to pass through into the blood stream. When something goes wrong, the tight junctions become permeable or “open” and allow un-screened molecules through the border and into the bloodstream. Examples of things that can get through in this situation are bacteria, pathogens, yeast, incompletely digested food, lectins and more. That’s why we call it a leaky gut. As this process continues over time, the intestinal lining can become damaged and even leakier, allowing even more “undesirables” through the intestinal wall and directly into the bloodstream. Typically, this increase in offenders in the blood will make the liver and kidneys work that much harder to filter it all out. As the gut becomes increasingly damaged, the liver or kidneys may not be able to keep up with the constant flow of bacteria, pathogens, yeast, undigested macro-nutrients and waste products escaping through the gut lining. As more invaders get through, overworking and overwhelming liver and kidneys, they are able to wreak havoc systemically (throughout the body). When these offenders attach to the cells lining the gut, an immune response is triggered which can lead to collateral damage of healthy cells. This can lead to another chain of events in which the immune system begins to recognize certain molecules from food as invaders, calls for an immune response whenever you eat those foods, which can then cause even more collateral damage. This collateral damage can be experienced as bloating, cramps, diarrhea, inflammation, joint pain, skin rashes, headaches, malabsorption and more. As the result of continuous immune response and corresponding collateral damage, the gut becomes more and more damaged. If you are frequently eating foods that it recognizes as an invader – it has no time to heal. Healthy cells are destroyed and those microvilli we talked about earlier are not able to do their job, which prevents your body from getting all the nutrients that you need, which in turn leads to all sorts of problems such as a weakened immune system or nutritional deficiencies. To make matters worse, as your immune systems weakens, you become more susceptible to illness from the stream of junk (toxins, bacteria, pathogens, etc.) flowing through your leaky gut. If this vicious cycle continues for weeks or months or years, you body may ultimately end up fighting itself, potentially leading to the initiation of autoimmune diseases such as as Crohn’s disease, ulcerative colitis, multiple sclerosis, type 1 diabetes, lupus, rheumatoid arthritis, chronic fatigue syndrome, fibromyalgia, vasculitis, urticaria (hives), alopecia areata, polymyalgia rheumatica, Raynaud’s syndrome, vitiligo, thyroiditis, and Sjogren’s syndrome. With me so far? Great! Let’s go deeper and talk about the probable triggers that start off this awful process. The Hidden Causes Some of the most interesting emerging research regarding digestion and autoimmune disease has to do with a few factors that could be triggers for opening the draw bridge (tight junctions) of the gut. A few key factors that appear to be the likely causes of leaky gut are zonulin, gluten (the gliadin portion), and some lectins. Zonulin Zonulin is a protein that modulated the permeability of the tight junctions in the gut. So far, it is the only “key” that we know the human body produces. Zonulin upregulation has been implicated in the pathogenesis of several autoimmune diseases including celiac and type 1 diabetes. Zonulin is currently being studied as a potential target for celiac treatment. Gliadin Gliadin (1/2 of the protein complex we commonly refer to as gluten) has been shown to active (upregulate) zonulin signaling in everyone, regardless of celiac status, leading to the opening of tight junctions in the gut and leading to increased gut permeability. Gliadin is found in wheat, barley, rye, and triticale, which are all grains found nearly everywhere in our modern food supply. There are three main types

Gluten-Free: History of a Movement

by Robert Prowse in Articles November 17, 2022

The history of the gluten-free movement is both interesting and relevant to more and more people every day. Most likely, gluten sensitivity and celiac disease have been with humans ever since our ancestors started eating grains. The first record of the symptoms of celiac disease comes from 100 AD when the Greek physician, Aretaeus the Cappadocian, known as Galen, described the characteristic stool of celiac patients. Anthropologists recently found the bones of a young Roman woman who appears to have died from chronic malnutrition due to celiac disease. There are “bread-crumbs” to follow from ancient to modern times indicating that people have more or less always suffered from ingestion of gluten. What is less clear is what has happened in the last couple of decades that has increased the prevalence of celiac disease and non-celiac gluten sensitivity. There has been a four-fold increase in the diagnosis of celiac disease between 1990 and 2012 and it is believed that two-thirds of celiac cases go undiagnosed. It is hard to make statements on the prevalence of non-celiac gluten sensitivity but it is easy to see that it has increased since it was not a recognized condition as recently as 10 years ago. There is, however, evidence to suggest that it may affect as many as 1 in 20 Americans. Where does this increase come from? Before we look at the factors that led to this increase, check out this infograph of great moments in the gluten-free movement’s history: There are many theories and explanations floating around but no consensus. As with most things in this world, the answer lies in the interaction between people and their environment. People are changing their behaviors and their environment is changing faster than ever before. Let’s take a look at these two areas and the factors within them. Behaviors More testing being performed Because celiac disease presents in so many ways, it is not easy to diagnose. Until a few decades ago, it was generally believed that celiac disease only produced a handful of very uniform symptoms: stomach cramping, chronic diarrhea, bloating, and weight loss. In the past 10-15 years, we have learned that celiac disease produces a much wider array of symptoms than previously believed. We now believe that symptoms of celiac disease may also include chronic headaches, malnutrition, arthritis, skin rashes, osteoporosis, infertility, anxiety, depression, and even epilepsy in rare cases. This leads physicians to consider and test for celiac disease more often than they previously would have. The tests themselves are better as well. In the past, tests relied on multiple intestinal biopsies, which required an individual to eat a gluten-containing diet for several weeks or longer. The tests would not necessarily catch cases of “silent celiac” in which extra-intestinal issues were the main problem. Though we still do not have a standard for testing, the options available to practitioners include genetic tests and a variety of blood and stool biomarkers that are more accurate and less invasive. So the combination of more tests being performed and those tests catching the illness more often may be playing a role in the increased diagnosis of celiac disease. Of course, these factors alone cannot explain the increase in celiac disease and gluten spectrum disorders. More self-diagnosis In addition to the people being diagnosed by physicians, there are scores more who “self-diagnose” with gluten issues. “Gluten-free” has become popular so more people are trying it and, while not all of those people really need to avoid gluten, many of them find that they feel better after eliminating wheat from their diet. What may have started out as an experiment based on popularity becomes a real change for the better in many people’s lives. Environment Of course, our environment plays a big role in our behavior. There is a theory that part of the increase in gluten sensitivity spectrum disorders is due to increased consumption of gluten along with industrialized processing practices. (Wheat is often sprayed with herbicide just prior to harvest to increase yields and to act as a desiccant for drying.) Increased Exposure Speaking of processing, this is another way that we are getting exposed to more gluten than ever before. Because the food industry uses wheat and isolated gluten as filler in many products – things like soups, sauces, dietary supplements, even white pepper – we are often unknowingly consuming more gluten than just what we find in baked goods. Gut Bacteria There is an interesting theory that certain types of bacteria that can colonize our gut have an effect on the risk of developing gluten intolerance. This is a perfectly feasible theory as our gut bacteria perform many functions in digestion, immunity, hormone regulation, and even behavior. We do not yet have a complete understanding of all species of gut bacteria and what they are capable of. What Does the “Gluten-Free” Future Hold? Though we can not say for certain why there has been such a huge increase in the number of people diagnosed with celiac disease and the number of people feeling the effects of non-celiac gluten sensitivity, we know that a rise in awareness has been a boon to those suffering from gluten issues. There are more gluten-free products available than ever before for those with celiac disease who must be on an entirely gluten-free diet. Correspondingly, there has been a significant increase in the amount of research being done into celiac disease and non-celiac gluten intolerance. This means that more solutions are being introduced to the market and a greater understanding is developing within the healthcare community. Because of the way our food supply is currently structured, gluten will remain in our lives for decades to come and “gluten-free” will continue its meteoric rise in public awareness. The smartest thing we can do is to find ways to reduce the risk that not being gluten-free poses to us. How to Protect Yourself From Gluten Even if you do not experience acute symptoms, there is good evidence that the gluten in your

Gluten Sensitivity

by Robert Prowse in Articles, Gluten Sensitivity January 4, 2021

How Bad is the Problem? Gluten sensitivity is a condition that causes a wide range of symptoms including indigestion, bloating, abdominal pain, joint pain, fatigue, headaches/migraines, and brain fog whenever an affected person eats gluten-containing foods. Though people suffering from gluten sensitivity experience many of the same symptoms as people with celiac disease, it is not the same condition. Though the topic of this article about gluten, we are just getting started with identifying things in foods we eat every day that are bad for our body and from which we need protection. We cannot pin down exactly how many people are affected by gluten sensitivity because it is so hard to diagnose. Researchers estimate that it may be as many as 1 in 20 Americans. How Do I Know If I Am Gluten Sensitive? Currently, there is no procedure for physicians to follow in order to diagnose gluten sensitivity but there are a few questions that you can ask yourself to determine if you may have this condition. Do you experience indigestion or upset stomach, especially after eating bread or processed foods? Do you have frequent headaches, suffer from migraines or have trouble focusing? Do you feel tired after eating? Do you have joint pain? If you answered yes to one or more of these questions, your problems may be caused by sensitivity to gluten. What I can do to find relief? Traditionally the treatment for both celiac disease and gluten sensitivity has been the total avoidance of gluten. It is still true that a gluten-free diet is the only way to treat celiac disease but people with gluten sensitivity now have another option. Shield Nutraceuticals has developed a new co-probiotic dietary supplement designed to aid in the digestion of gluten, processed foods and more. DigestShield® DigestShield®, the world’s first co-probiotic, works to break down gluten, dairy, carbohydrates, fat, and protein with a synergistic blend of enzymes, prebiotics, and probiotics. It is the only product of its type on the market and is an all-in-one digestive powerhouse. Each DigestShield® capsule contains 20 different enzymes, 5 Prebiotics (including 200 milligrams of vegetarian, ultra-low molecular weight chitosan), and 11 probiotic strains to help protect you from gluten, processed food, and other “bad actors” in your diet and get your gut flora back in balance. DigestShield® is specially formulated to help maintain a proper balance of intestinal microflora, inhibit pathogenic bacteria and prevent the overgrowth of yeast organisms, including Candida. Candida albicans is usually a harmless yeast present in the body. However, stress, in the form of modern lifestyles, hormonal imbalances, excessive sugar consumption, environmental pollutants, and pharmaceutical drugs, including antibiotics and oral contraceptives, can wreak havoc on the proper balance of microorganisms in the gastrointestinal tract. Candida, being an opportunistic organism, will flourish under these adverse conditions. And when Candida is anchored to the intestinal tract, intestinal leakage and immune disorders may result. Candida removal is the logical first step toward effective intestinal cleansing. The protease enzyme Serrapeptase and enzymes like Cellulase and Chitosanase attack the outer cell wall of Candida yeast, weakening its hold on the intestinal mucosa and reducing their viability. Here are some of the ways DigestShield® distinguishes itself from other intestinal balancing formulas: Chitosan Oligosaccharide, derived from the cell wall of the oyster mushroom and hydrolyzed to an ultra-low molecular weight of just 3 kDa, is a unique prebiotic that will attach itself to lectins found in many of the foods we eat (including wheat and soy) so they won’t attach to the epithelial cells lining our gut. This can help prevent leaky gut. Bacillus Coagulans is a special spore-forming probiotic that is incredibly stable in the dormant state. Using our Enhanced Probiotic Delivery System™(EPDS), this probiotic can exist in a dehydrated state indefinitely. EPDS™ delivers larger amounts of living bacteria into the intestinal tract, where they colonize and flourish. Once in the intestinal tract, these bacteria exit their spores, attach themselves to the intestinal mucosa, and begin to germinate, producing new colonies of friendly bacteria. Fructooligosaccharides (FOS), nutrient-dense alfalfa, and papaya powder comprise a fortified prebiotic blend, which enhances the growth and stability of probiotics in the gut. High-activity proteases, including Peptizyme-SP brand serrapeptase, hydrolyze putrefying food matter trapped between the intestinal villi, which can cause sluggish digestion, bloating, and an increase in toxins. These enzymes create a better intestinal environment, improved absorption, motility, and better overall colon health. The recommended dosage is 1-2 capsules before each meal and or 1-2 capsules at bedtime. Every bottle comes with a 100% money-back double guarantee. Order yours today!

Tag Archives: leaky gut

Bad Actors

In-Depth Look at Dietary Bad Actors

Lectins: The Gluten-Lectin-Leaky Gut Connection

Gluten-Free: History of a Movement

Gluten Sensitivity

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